The Engineering Management concentration in the Master of Science in Professional Science degree was created to provide engineers, scientists, and technicians with the business and management tools needed for leadership positions in manufacturing and industry. Designed for working professionals, the program can be completed on a part-time basis over two years; classes are held primarily in the evening, and many are online. The program helps equip students with skills (including project management, Six Sigma, and lean manufacturing) to implement and manage competitive process innovations and product development.

The Chemistry Analytics concentration in the Master of Science in Professional Science degree provides managerial skills as well as advanced training in chemistry to allow graduates to advance to more supervisory levels within their companies. Students will be trained in the analysis of data from modern analytical instrumentation, such as gas and liquid chromatography, uv, visible and infrared spectroscopy, flame emission, atomic absorption, and mass spectrometry (CHEM 6230) used in industrial settings with examples drawn from the literature to illustrate application to real-world problems (CHEM 6210).

The Biostatistics concentration in the Master of Science in Professional Science degree offers training in the statistical methods applied to medicine, biology, public health, and the development of new tools to study these areas. These methods involve using mathematics to solve real-world problems that influence health decision processes. Biostatisticians utilize their qualitative skills to work with experts in related health and physical science disciplines to analyze, evaluate, and interpret the results to better inform the field and turn complex datasets into scientifically sound, actionable findings.

The MTSU Department of Aerospace offers three Master of Science in Aeronautical Science concentrations. The Aviation Management concentration is a management and operations-oriented degree program designed in cooperation with industry representatives. The study focuses on airport activities and organizational structures, aviation contracts and leases, and aviation systems management. The Aviation Education concentration is designed to serve students interested in the conduct of aviation education, training, or professional development programs, or in the administration of such programs. Students in this concentration take classes in both the Aerospace Department and MTSU College of Education. The Safety and Security Management concentration is designed to provide students the knowledge and expertise necessary to develop and manage aviation safety and security programs. Studies include safety management systems (SMS), aviation security, aviation safety investigation, and human factors in aviation.

The Master of Science in Professional Science is a groundbreaking master's degree in the sciences, technology, engineering, and mathematics (STEM) disciplines that helps equip students for work in public and private business enterprises and in academia. Well-suited to both working professionals as well as traditional students, this program emphasizes the skills and experience that will prepare the next generation of professionals to be competitive in the business and healthcare information technology workforce.

The Fermentation Science concentration in the Master of Science in Professional Science degree emphasizes the skills and experience that will prepare the next generation of professionals for the broad range of industries that employ fermentation to create end products, including the food, chemical, pharmaceutical, and water treatment industries. Through the curriculum of core business classes, the graduate is better prepared to assume management and leadership roles within any industry utilizing fermentation.

Actuarial science is a special discipline for training students to apply mathematical skills and statistical techniques to study uncertain future events, especially those of concern to insurance and pension programs. The Actuarial Science concentration in the Master of Science in Professional Science degree offers preparation, basic knowledge, and professional skills to work as an actuary and to pass actuarial professional examinations. The program offers training so that students can make practical use of probability theory and statistical analysis for managing risks and solving practical problems.

Mathematics is the study of quantity, structure, space, and change. Exploring and understanding the world in which we live is increasingly a matter of mathematical inquiry and discovery. Laptops, smartphones, and video game consoles rely on mathematics, as do the techniques engineers and empirical scientists use to probe nature. Consequently, there is growing need for individuals capable of "speaking the language" of mathematics.

The Biotechnology concentration in the Master of Science in Professional Science degree offers preparation for careers in the management of bioscience firms and organizations. The program is a combination of business and science to offer training to work in highly skilled and/or leadership roles in scientific companies and agencies.

MTSU’s Master of Science in Finance program is designed to provide a graduate-level knowledge base and expertise to those who work in the growing field of finance, assisting individuals, companies, and governments in navigating the increasingly complex and essential world of financial analysis. The program is ideal for a prospective student with a business/quantitative background (e.g. finance, economics, accounting, mathematics, or engineering undergraduate degree) who is seeking to advance his/her career in the rewarding world of finance. The 12-month, 33-credit hour program offers a class schedule to accommodate professionals in the work world as well as full-time students. The program aims to impart quantitative, practical knowledge in various areas within the field of finance; deliver hands-on experience applying various financial modeling and valuation concepts, tools, and techniques; and develop communication, critical thinking, analytical ethical decision making, and discipline-specific skills.

At the graduate level, the Chemistry Department features a research-based Master of Science degree. After completion of core coursework in the major sub-disciplines, students in the Chemistry M.S. program have the opportunity to participate in a wide range of research experiences, including environmental, organic synthesis, natural product isolation, computational and theoretical, analytical, nanomaterials, catalysis, polymers, biochemistry, and chemical education. The research experience is considerably enhanced by MTSU’s new 250,000-square-foot science building and upgraded instrumentation. Talented undergraduates also have the opportunity to participate in a new Accelerated Bachelor’s/Master’s (ABM) program which enables them to complete a bachelor’s and master’s degree in five years. Graduates find employment in a wide range of areas as well as continuing their education in high-quality doctoral and/or professional programs. The department also participates in three interdisciplinary Ph.D. programs (Molecular Biosciences, Computational Science, and Math and Science Education).